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Phenotypic and functional characterization of first-trimester human placental macrophages, Hofbauer cells

12 Sept 2020

Abstract excerpt

Hofbauer cells (HBCs) are a population of macrophages found in high abundance within the stroma of the first-trimester human placenta. HBCs are the only fetal immune cell population within the stroma of healthy placenta. However, the functional properties of these cells are poorly described. Aligning with their predicted origin via primitive hematopoiesis, we find that HBCs are transcriptionally similar to yolk...

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PMID: 33075123
DOI: 10.1084/jem.20200891

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