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Article

Necrotic cardiac myocytes skew macrophage polarization towards a classically activated phenotype.

PloS one - 1 Jan 2023

Jiang Wenlong, Adamo Luigi, Lim Kenji, Matkovich Scot J, Evans Sarah, Rocha-Resende Cibele, Mann Douglas L

Abstract excerpt

Necrotic and dying cells release damage-associated molecular patterns (DAMPs) that can initiate sterile inflammatory responses in the heart. Although macrophages are essential for myocardial repair and regeneration, the effect of DAMPs on macrophage activation remains unclear. To address this gap in knowledge we studied the effect of necrotic cardiac myocyte extracts on primary peritoneal macrophage (PPM)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36996254
DOI: 10.1371/journal.pone.0282921
PMCID: PMC10062615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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