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Article

Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43.

International journal of molecular sciences - 14 Mar 2023

Kitamura Akira, Yuno Sachiko, Kawamura Rintaro, Kinjo Masataka

Abstract excerpt

Transactive response element DNA/RNA-binding protein 43 kDa (TDP-43) is the causative protein of amyotrophic lateral sclerosis (ALS); several ALS-associated mutants of TDP-43 have been identified. TDP-43 has several domains: an N-terminal domain, two RNA/DNA-recognition motifs, and a C-terminal intrinsically disordered region (IDR). Its structures have been partially determined, but the whole structure remains...

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Identifiers

PMID: 36982587
DOI: 10.3390/ijms24065513
PMCID: PMC10056606

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