Article
Association of NEF2L2 Rs35652124 Polymorphism with Nrf2 Induction and Genotoxic Stress Biomarkers in Autism.
Genes - 15 Mar 2023
Porokhovnik Lev N, Pisarev Vladimir M, Chumachenko Anastasia G, Chudakova Julia M, Ershova Elizaveta S, Veiko Natalia N, Gorbachevskaya Natalia L, Mamokhina Uliana A, Sorokin Alexander B, Basova Anna Ya, Lapshin Mikhail S, L Izhevskaya Vera, Kostyuk Svetlana V
Abstract excerpt
Increased oxidative/genotoxic stress is known to impact the pathophysiology of ASD (autism spectrum disorder). Clinical studies, however, reported limited, heterogeneous but promising responses to treatment with antioxidant remedies. We determined whether the functional polymorphism of the Nrf2 gene, master regulator of anti-oxidant adaptive reactions to genotoxic stress, links to the genotoxic stress responses...
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