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Article

Evolutionary Origin of MUTYH Germline Pathogenic Variations in Modern Humans.

Biomolecules - 24 Feb 2023

Xiao Fengxia, Li Jiaheng, Lagniton Philip Naderev Panuringan, Kou Si Hoi, Lei Huijun, Tam Benjamin, Wang San Ming

Abstract excerpt

MUTYH plays an essential role in preventing oxidation-caused DNA damage. Pathogenic germline variations in MUTYH damage its function, causing intestinal polyposis and colorectal cancer. Determination of the evolutionary origin of the variation is essential to understanding the etiological relationship between MUTYH variation and cancer development. In this study, we analyzed the origins of pathogenic germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36979362
DOI: 10.3390/biom13030429
PMCID: PMC10046817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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