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Article

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

Nature genetics - 1 Aug 2010

Hirschfield Gideon M, Liu Xiangdong, Han Younghun, Gorlov Ivan P, Lu Yan, Xu Chun, Lu Yue, Chen Wei, Juran Brian D, Coltescu Catalina, Mason Andrew L, Milkiewicz Piotr, Myers Robert P, Odin Joseph A, Luketic Velimir A, Speiciene Danute, Vincent Catherine, Levy Cynthia, Gregersen Peter K, Zhang Jinyi, Heathcote E Jenny, Lazaridis Konstantinos N, Amos Christopher I, Siminovitch Katherine A

Abstract excerpt

We genotyped individuals with primary biliary cirrhosis and unaffected controls for suggestive risk loci (genome-wide association P < 1 x 10(-4)) identified in a previous genome-wide association study. Combined analysis of the genome-wide association and replication datasets identified IRF5-TNPO3...

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Identifiers

PMID: 20639879
DOI: 10.1038/ng.631
PMCID: PMC2929126

Genes

TNPO3
MMEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20639879-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.PMID 20639879Read ↗

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