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Article

Pancreatic cancer cluster region identified in BRCA2.

Journal of medical genetics - 1 Nov 2023

Chian Jia Sheng, Xu Wenzheng, Wang San Ming

Abstract excerpt

Pancreatic cancer has a poor prognosis. Lack of diagnostic markers prevents its early diagnosis and treatment. Pathogenic germline variation in BRCA1 and BRCA2 (BRCA) is genetic predisposition for cancer. The location of variants in different regions in BRCA is non-randomly enriched in different types of cancer as shown by the breast cancer cluster region (BCCR), ovarian cancer cluster region (OCCR) and prostate...

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Identifiers

PMID: 36977549
DOI: 10.1136/jmg-2022-109111

Genes

BRCA2
BRCA1

Provenance

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