Article
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist.
The Journal of clinical investigation - 15 May 2023
Nichols David P, Morgan Sarah J, Skalland Michelle, Vo Anh T, Van Dalfsen Jill M, Singh Sachinkumar Bp, Ni Wendy, Hoffman Lucas R, McGeer Kailee, Heltshe Sonya L, Clancy John P, Rowe Steven M, Jorth Peter, Singh Pradeep K
Abstract excerpt
BackgroundLung infections are among the most consequential manifestations of cystic fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs called CF transmembrane conductance regulator (CFTR) modulators improve activity of dysfunctional CFTR channels, which is the physiological defect causing CF. However, it is unclear how improved CFTR activity affects CF lung...
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