Article

Remodelling of cystic fibrosis respiratory microbiota in response to extended Elexacaftor–Tezacaftor–Ivacaftor therapy

2025-12-01

Abstract excerpt

<h4>Background</h4> Cystic fibrosis (CF) has profoundly changed since the introduction of CF Transmembrane Conductance Regulator modulator therapies (CFTRmt), a class of medications that improve function of the CFTR protein encoded by certain CF-causing gene mutations. Amongst these, the triple combination therapy elexacaftor-tezacaftor-ivacaftor (ETI) has been the most impactful and widely used to date. Given ch...

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Literature Corpus work: ed8eeef7-a7e6-5074-8d89-d48dbb798060
DOI: 10.1101/2025.11.27.25341148

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