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Article

Mutual Effects of Single and Combined CFTR Modulators and Bacterial Infection in Cystic Fibrosis.

Microbiology spectrum - 14 Feb 2023

Cigana Cristina, Giannella Ruggero, Colavolpe Alice, Alcalá-Franco Beatriz, Mancini Giulia, Colombi Francesca, Bigogno Chiara, Bastrup Ulla, Bertoni Giovanni, Bragonzi Alessandra

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators improve clinical outcomes with varied efficacies in patients with CF. However, the mutual effects of CFTR modulators and bacterial adaptation, together with antibiotic regimens, can influence clinical outcomes. We evaluated the effects of ivacaftor (IVA), lumacaftor (LUM), tezacaftor, elexacaftor, and a three-modulator combination of...

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Identifiers

PMID: 36625583
DOI: 10.1128/spectrum.04083-22
PMCID: PMC9927584

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