Article
Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections.
mBio - 21 Dec 2021
Durfey Samantha L, Pipavath Sudhakar, Li Anna, Vo Anh T, Ratjen Anina, Carter Suzanne, Morgan Sarah J, Radey Matthew C, Grogan Brenda, Salipante Stephen J, Welsh Michael J, Stoltz David A, Goss Christopher H, McKone Edward F, Singh Pradeep K
Abstract excerpt
Drugs called CFTR modulators improve the physiologic defect underlying cystic fibrosis (CF) and alleviate many disease manifestations. However, studies to date indicate that chronic lung infections that are responsible for most disease-related mortality generally persist. Here, we investigated whether combining the CFTR modulator ivacaftor with an intensive 3.5-month antibiotic course could clear chronic...
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