Article
Impact of concurrent tumour events on the prostate cancer outcomes of germline BRCA2 mutation carriers.
European journal of cancer (Oxford, England : 1990) - 1 May 2023
Lozano Rebeca, Castro Elena, Lopez-Campos Fernando, Thorne Heather, Ramirez-Backhaus Miguel, Aragon Isabel M, Cendón-Florez Ylenia, Gutierrez-Pecharroman Ana, Salles Daniela C, Romero-Laorden Nuria, Lorente David, González-Peramato Pilar, Calatrava Ana, Alonso Concepción, Anido Urbano, Arévalo-Lobera Sara, Balmaña Judith, Chirivella Isabel, Juan-Fita María José, Llort Gemma, Y Cajal Teresa Ramón, Almagro Elena, Alameda Daniel, López-Casas Pedro P, Herrera Bernardo, Mateo Joaquin, Pritchard Colin C, Antonarakis Emmanuel S, Lotan Tamara L, Rubio-Briones José, Sandhu Shahneen, Olmos David
Abstract excerpt
BACKGROUND: Several studies have reported the association of germline BRCA2 (gBRCA2) mutations with poor clinical outcomes in prostate cancer (PCa), but the impact of concurrent somatic events on gBRCA2 carriers survival and disease progression is unknown. PATIENTS AND METHODS: To ascertain the role of frequent somatic genomic alterations and histology subtypes in the outcomes of gBRCA2 mutation carriers and...
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