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Article

Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Lanooij Suzanne D, Eisel Ulrich L M, van der Zee Eddy A, Kas Martien J H

Abstract excerpt

BACKGROUND: Altered social behavior is one of the symptoms of Alzheimer's disease (AD) that results in social withdrawal and loneliness and provides a major burden on patients and their relatives. Furthermore, loneliness is associated with an increased risk to develop AD and related dementias. OBJECTIVE: We aimed to investigate if altered social behavior is an early indicator of amyloid-β (Aβ) pathology in J20...

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Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Disease Models, Animal
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

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Identifiers

PMID: 36970900
DOI: 10.3233/JAD-221126
PMCID: PMC10200156

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