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Article

Inactivation of Notch4 Attenuated Pancreatic Tumorigenesis in Mice

15 Nov 2022

Abstract excerpt

Expression of the Notch family of receptors is often upregulated in pancreatic ductal adenocarcinoma (PDAC). In this study, we focused on Notch4, which had not been investigated in PDAC. We generated KC (LSL-KrasG12D;p48-Cre), N4−/−KC (Notch4−/−;LSL-KrasG12D;p48-Cre), PKC (p16fl/fl;LSL-KrasG12D;p48-Cre), and N4−/−PKC (Notch4−/−; p16fl/fl;LSL-KrasG12D;p48-Cre) genetically engineered mouse models (GEMM). We...

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PMID: 36970723
DOI: 10.1158/2767-9764.crc-22-0106

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