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Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice

4 Feb 2022

Abstract excerpt

Protein kinase C iota (PKCι) functions as a bonafide human oncogene in lung and ovarian cancer and is required for KrasG12D-mediated lung cancer initiation and progression. PKCι expression is required for pancreatic cancer cell growth and maintenance of the transformed phenotype; however, nothing is known about the role of PKCι in pancreas development or pancreatic tumorigenesis. In this study, we investigated...

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Share to Autophagy in Disease and Therapy
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PMID: 35159064
DOI: 10.3390/cancers14030796

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