Article
Understanding the genetic basis of gastric cancer: recent advances.
Expert review of gastroenterology & hepatology - 1 Jun 2012
Tan Iain Beehuat, Ng Isabel, Tai Wai Meng, Tan Patrick
Abstract excerpt
Two major gastric cancer histological subtypes are recognized with distinct morphology, epidemiology, pathogenesis and clinical behavior. Genetically, the intestinal and diffuse subtypes are also characterized by distinct germline susceptibility patterns and somatic aberrations. Helicobacter pylori is strongly associated with both Lauren's subtypes, although the underlying carcinogenic mechanisms are unique. Risk...
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