Article
RUNX1 together with DAT mutations predicted poor outcome in acute myeloid leukemia.
Leukemia & lymphoma - 1 May 2023
Xiao Jinyan, Xie Jundan, Zhou Biqi, Liu Yujie, Lu Jing, Jiang Airui, Yao Hong, Qiu Qiaocheng, Ding Zixuan, Xue Shengli, Tang Xiaowen, Qiu Huiying, Chen Suning, Shen Hongjie, Wu Depei, Xu Yang
Abstract excerpt
We retrospectively explored the prognostic impact of DAT mutations at diagnosis in 122 RUNX1mut AML patients. RUNX1 missense mutation was dominant in the RUNT domain, and frameshift mutation was dominant in the TAD domain. DAT mutations occurred in 38.5% of RUNX1mut AML. After propensity score matching, DATpos patients had worse two-year relapse-free survival (RFS) than DATneg patients (p = .041). Moreover,...
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