Article
The C-terminal mutation beyond the catalytic site of brown spider phospholipase D significantly impacts its biological activities.
Biochimie - 1 Aug 2023
Cunha Laís Cardoso, Barreto Lucas Passos, Valadares Veronica Silva, Oliveira Camila Franco Batista, Vuitika Larissa, Vilela Maura Páscoa, Cino Elio A, Silva Adolfo Henrique de Moraes, Nagem Ronaldo A P, Chávez-Olórtegui Carlos, Dias-Lopes Camila, Molina Franck, Felicori Liza
Abstract excerpt
Loxosceles spider envenomation results in dermonecrosis, principally due to phospholipases D (PLDs) present in the venom. These enzymes have a strongly conserved sequence, 273ATXXDNPW280, in the C-terminal region (SMD-tail) that make contact with β-sheets of the TIM barrel, in which the amino acids Asp277 and Trp280 establish the energetically strongest contacts. The SMD-tail is conserved in PLDs from different...
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