Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).

The Biochemical journal - 15 Oct 2005

Lee Sangderk, Lynch Kevin R

Abstract excerpt

Envenomation by the brown recluse spider (Loxosceles reclusa) may cause local dermonecrosis and, rarely, coagulopathies, kidney failure and death. A venom phospholipase, SMaseD (sphingomyelinase D), is responsible for the pathological manifestations of envenomation. Recently, the recombinant SMaseD from Loxosceles laeta was demonstrated to hydrolyse LPC (lysophosphatidylcholine) to produce LPA (lysophosphatidic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysophospholipids

Share to Phospholipase D

Share to Phosphoric Diester Hydrolases

Share to Point Mutation

Share to Spiders

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 15926888
DOI: 10.1042/BJ20050043
PMCID: PMC1276930

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA).PMID 15926888Read ↗

Brown spider phospholipase-D containing a conservative mutation (D233E) in the catalytic site: identification and functional characterization.Semantic proximity Read ↗

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features.Semantic proximity Read ↗

The C-terminal mutation beyond the catalytic site of brown spider phospholipase D significantly impacts its biological activities.Semantic proximity Read ↗

Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom.Semantic proximity Read ↗

Phospholipase C-delta and related molecules.Semantic proximity Read ↗

Characterisation of functional and insecticidal properties of a recombinant cathepsin L-like proteinase from flesh fly (Sarcophaga peregrina), which plays a role in differentiation of imaginal discs.Semantic proximity Read ↗

Comparative analyses of venoms from American and African Sicarius spiders that differ in sphingomyelinase D activity.Semantic proximity Read ↗

A Novel Acidic Myotoxic Phospholipase A<sub>2</sub> of Colombian <em>B. asper</em> Venom. Isolation and Functional CharacterizationSemantic proximity Read ↗

Purification, analysis, and enzymatic activity of recombinant human synovial fluid phospholipase A2 and N-terminal variants.Semantic proximity Read ↗

Functional expression and characterization of a recombinant phospholipase A2 from sea snake Lapemis hardwickii as a soluble protein in E. coli.Semantic proximity Read ↗

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.Semantic proximity Read ↗

Phospholipase A2 plays an important role in myelin breakdown and phagocytosis during Wallerian degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.