Article
Crystallization and preliminary X-ray diffraction analysis of a class II phospholipase D from Loxosceles intermedia venom.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Feb 2011
Ullah Anwar, de Giuseppe Priscila Oliveira, Murakami Mario Tyago, Trevisan-Silva Dilza, Wille Ana Carolina Martins, Chaves-Moreira Daniele, Gremski Luiza Helena, da Silveira Rafael Bertoni, Sennf-Ribeiro Andrea, Chaim Olga Meiri, Veiga Silvio Sanches, Arni Raghuvir Krishnaswamy
Abstract excerpt
Phospholipases D are the major dermonecrotic component of Loxosceles venom and catalyze the hydrolysis of phospholipids, resulting in the formation of lipid mediators such as ceramide-1-phosphate and lysophosphatidic acid which can induce pathological and biological responses. Phospholipases D can be classified into two classes depending on their catalytic efficiency and the presence of an additional disulfide...
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