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Article

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features.

Biochimica et biophysica acta - 1 Sept 2016

Vuitika L, Chaves-Moreira D, Caruso I, Lima M A, Matsubara F H, Murakami M T, Takahashi H K, Toledo M S, Coronado M A, Nader H B, Senff-Ribeiro A, Chaim O M, Arni R K, Veiga S S

Abstract excerpt

Brown spider phospholipases D from Loxosceles venoms are among the most widely studied toxins since they induce dermonecrosis, triggering inflammatory responses, increase vascular permeability, cause hemolysis, and renal failure. The catalytic (H12 and H47) and metal-ion binding (E32 and D34) residues in Loxosceles intermedia phospholipase D (LiRecDT1) were mutated to understand their roles in the observed...

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PMID: 27233517
DOI: 10.1016/j.bbalip.2016.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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