Article
A large-scale exome array analysis of venous thromboembolism.
Genetic epidemiology - 1 Jun 2019
Lindström Sara, Brody Jennifer A, Turman Constance, Germain Marine, Bartz Traci M, Smith Erin N, Chen Ming-Huei, Puurunen Marja, Chasman Daniel, Hassler Jeffrey, Pankratz Nathan, Basu Saonli, Guan Weihua, Gyorgy Beata, Ibrahim Manal, Empana Jean-Philippe, Olaso Robert, Jackson Rebecca, Braekkan Sigrid K, McKnight Barbara, Deleuze Jean-Francois, O'Donnell Cristopher J, Jouven Xavier, Frazer Kelly A, Psaty Bruce M, Wiggins Kerri L, Taylor Kent, Reiner Alexander P, Heckbert Susan R, Kooperberg Charles, Ridker Paul, Hansen John-Bjarne, Tang Weihong, Johnson Andrew D, Morange Pierre-Emmanuel, Trégouët David A, Kraft Peter, Smith Nicholas L, Kabrhel Christopher
Abstract excerpt
Although recent Genome-Wide Association Studies have identified novel associations for common variants, there has been no comprehensive exome-wide search for low-frequency variants that affect the risk of venous thromboembolism (VTE). We conducted a meta-analysis of 11 studies comprising 8,332 cases and 16,087 controls of European ancestry and 382 cases and 1,476 controls of African American ancestry genotyped...
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