Article
Multicenter retrospective analysis of clinical outcome of adult patients with mixed-phenotype acute leukemia treated with acute myeloid leukemia-like or acute lymphoblastic leukemia-like chemotherapy and impact of allogeneic stem cell transplantation: a Campus ALL study.
Annals of hematology - 1 May 2023
Lazzarotto Davide, Tanasi Ilaria, Vitale Antonella, Piccini Matteo, Dargenio Michelina, Giglio Fabio, Forghieri Fabio, Fracchiolla Nicola, Cerrano Marco, Todisco Elisabetta, Papayannidis Cristina, Leoncin Matteo, Defina Marzia, Guolo Fabio, Pasciolla Crescenza, Delia Mario, Chiusolo Patrizia, Mulè Antonino, Candoni Anna, Bonifacio Massimiliano, Pizzolo Giovanni, Foà Robin
Abstract excerpt
Mixed-phenotype acute leukemia (MPAL) is a rare disease. Treatment is often similar to that of acute lymphoblastic leukemia (ALL), but the outcome in adults and the role of allogeneic stem cell transplantation (AlloSCT) are not well defined. We report on 77 adult patients diagnosed with MPAL over the last 10 years and treated with a curative intent. Median age was 49 years; 7.6% of cases had a BCR::ABL1...
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