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Outcomes with high dose cytarabine and mitoxantrone induction for adults with mixed phenotype acute leukemia.

Leukemia research - 1 Jul 2023

Atchley Evan, Weis Taylor M, Derkach Andriy, Galera Pallavi K, Xiao Wenbin, Glass Jacob, DeWolf Susan, Roshal Mikhail, Shah Richa, Stump Sarah E

Abstract excerpt

The optimal induction strategy for mixed phenotype acute leukemia (MPAL) is unknown, though retrospective data has shown improved remission rates and overall survival with acute lymphoblastic leukemia (ALL)-based regimens. At Memorial Sloan Kettering Cancer Center (MSKCC), the most utilized induction regimen for MPAL is high dose cytarabine plus mitoxantrone ("ALL-2"), though outcomes with this regimen are not...

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Identifiers

PMID: 37182399
DOI: 10.1016/j.leukres.2023.107311

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