Article
UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.
eLife - 23 Mar 2023
Black Holly H, Hanson Jessica L, Roberts Julia E, Leslie Shannon N, Campodonico Will, Ebmeier Christopher C, Holling G Aaron, Tay Jian Wei, Matthews Autumn M, Ung Elizabeth, Lau Cristina I, Whiteley Alexandra M
Abstract excerpt
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS cases are caused by mutation of the proteasome shuttle factor Ubiquilin 2 (UBQLN2), but the molecular pathway leading from UBQLN2 dysfunction to disease remains unclear. Here, we demonstrate that UBQLN2 regulates the domesticated gag-pol retrotransposon...
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