Article

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

2022-03-27

Abstract excerpt

<h4>Summary</h4> Amyotrophic Lateral Sclerosis (ALS) is a fatal, neurodegenerative disease characterized by progressive motor neuron dysfunction and loss. A portion of ALS is caused by mutation of the proteasome shuttle factor Ubiquilin 2 ( UBQLN2) , but the molecular pathway leading from UBQLN2 dysfunction to disease remains unclear. Here, we demonstrate a function of UBQLN2 in regulating activity of the domes...

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Literature Corpus work: 37f9dead-6452-5d66-9917-c85b05832269
DOI: 10.1101/2022.03.25.485837

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