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A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth

22 Mar 2023

Abstract excerpt

Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin interaction maps are compared to identify the spatial and temporal genome architectural changes during EBV B cell transformation. EBV induces global genome reorganization where contact domains frequently merge or subdivide during...

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PMID: 36949074
DOI: 10.1038/s41467-023-37347-6

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