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Article

Structural and Dynamic Differences between Calreticulin Mutants Associated with Essential Thrombocythemia.

Biomolecules - 10 Mar 2023

Radjasandirane Ragousandirane, de Brevern Alexandre G

Abstract excerpt

Essential thrombocythemia (ET) is a blood cancer. ET is characterized by an overproduction of platelets that can lead to thrombosis formation. Platelet overproduction occurs in megakaryocytes through a signaling pathway that could involve JAK2, MPL, or CALR proteins. CALR mutations are associated with 25-30% of ET patients; CALR variants must be dimerized to induce ET. We classified these variants into five...

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Identifiers

PMID: 36979444
DOI: 10.3390/biom13030509
PMCID: PMC10046389

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