Article
Calreticulin mutations in essential thrombocythemia and primary myelofibrosis.
Clinica chimica acta; international journal of clinical chemistry - 15 Sept 2026
Bhat Asif Ahmad, Fuloria Shivkanya, Thapa Riya, Agnihotri Supriya, Ansari Mohammed Tahir, Narain Kamal, Biswas Anupam, Biswas Sangita, Bhatia Sumita, Fuloria Neeraj Kumar
Abstract excerpt
Mutations in calreticulin have been identified as driver mutations in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) and are especially important for diagnostics and prognosis in primary myelofibrosis and essential thrombocythemia. The vast majority of pathogenic variants are insertions or deletions in exon 9 that result in a mutant C-terminal sequence that activates the signaling of the thrombopoietin...
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