Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface

16 Mar 2023

Abstract excerpt

BACKGROUND: This study aimed to delineate the cell heterogeneity in the bone-implant interface and investigate the fibroblast responses to implant-associated S. aureus infection. METHODS: Single-cell RNA sequencing of human periprosthetic tissues from patients with periprosthetic joint infection (PJI, n = 3) and patients with aseptic loosening (AL, n = 2) was performed. Cell type identities and gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Tissue Engineering Materials
Share to Orthopaedic implants and arthroplasty
Share to Orthopedic Infections and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36927352
DOI: 10.1186/s10020-023-00632-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interfacePMID 36927352Read ↗

Transcriptome Architecture of Osteoblastic Cells Infected With Staphylococcus aureus Reveals Strong Inflammatory Responses and Signatures of Metabolic and Epigenetic DysregulationSemantic proximity Read ↗

From cells to clinic: Single-cell transcriptomics shaping the future of orthopedicsSemantic proximity Read ↗

Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease ProgressionSemantic proximity Read ↗

Two reactive behaviors of chondrocytes in an IL-1β-induced inflammatory environment revealed by the single-cell RNA sequencingSemantic proximity Read ↗

Single-cell profiling uncovers synovial fibroblast subpopulations associated with chondrocyte injury in osteoarthritisSemantic proximity Read ↗

Single-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritisSemantic proximity Read ↗

Single-cell RNA sequencing in orthopedic researchSemantic proximity Read ↗

Integrative scRNA-seq and spatial transcriptomics uncovers distinct macrophage-fibroblast cross-talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritisSemantic proximity Read ↗

Understanding the Foreign Body Response via Single-Cell Meta-AnalysisSemantic proximity Read ↗

Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritisSemantic proximity Read ↗

Heterogeneity of Inflammation-associated Synovial Fibroblasts in Rheumatoid Arthritis and Its DriversSemantic proximity Read ↗

Drivers of heterogeneity in synovial fibroblasts in rheumatoid arthritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.