Malignant Chondroblastoma: An Epigenetically Distinct Subtype of Chondroblastoma With a Predilection for the Skeletally Mature.

doi:10.1016/j.modpat.2025.100790

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Article

Malignant Chondroblastoma: An Epigenetically Distinct Subtype of Chondroblastoma With a Predilection for the Skeletally Mature.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2025

Fritchie Karen, Ameline Baptiste, Andrei Vanghelita, Charville Greg, Hornick Jason L, Meredith David M, John Ivy, Michal Michael, Pancsa Tamas, Kilpatrick Scott E, Reith John, Wang Zhen, Horvai Andrew, Gross John, Sumathi Vaiyapuri, Davis Jessica L, Purgina Bibianna, Raymond Daniel P, Ilaslan Hakan, Chrisinger John, Din Nasir Ud, Hung Yin P, Nielsen Gunnlaugur P, Mogler Carolin, Papke David J, Baumhoer Daniel

Abstract excerpt

Malignant chondroblastoma is a recently described variant of chondroblastoma showing a distinct age/site distribution and morphology along with the typical H3-3B p.K36M mutation. We sought to further compare conventional and malignant chondroblastoma. Malignant chondroblastomas were collected. H3-3 K36M immunohistochemistry, as well as DNA methylation and copy number profiling, were performed and compared with...

Read the complete abstract on PubMed

Topics

Humans
Chondroblastoma
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Adult

Bone Neoplasms

Young Adult

Middle Aged

DNA Methylation

Epigenesis, Genetic

Biomarkers, Tumor

Mutation

Histones

DNA Copy Number Variations

Immunohistochemistry

Source

Open in PubMed

Identifiers

PMID: 40348060
DOI: 10.1016/j.modpat.2025.100790

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