Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma

29 Jun 2022

Abstract excerpt

Fibrolamellar carcinoma (FLC) is an aggressive liver cancer with no effective therapeutic options. The extracellular environment of FLC tumors is poorly characterized and may contribute to cancer growth and/or metastasis. To bridge this knowledge gap, we assessed pathways relevant to proteoglycans, a major component of the extracellular matrix. We first analyzed gene expression data from FLC and nonmalignant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Liver physiology and pathology
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36923282
DOI: 10.1158/2767-9764.crc-21-0177

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar CarcinomaPMID 36923282Read ↗

Chemical, molecular, and single cell analysis reveal chondroitin sulfate proteoglycan aberrancy in fibrolamellar carcinomaSemantic proximity Read ↗

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver diseaseSemantic proximity Read ↗

Identification of mRNA and lncRNA profiles and potential targeted agents for fibrolamellar carcinoma based on RNA-sequencing dataSemantic proximity Read ↗

Single Nucleus RNA Sequencing of Pre-Malignant Liver Reveals Disease-Associated Hepatocyte State with HCC Prognostic PotentialSemantic proximity Read ↗

Unique genomic profile of fibrolamellar hepatocellular carcinoma.Semantic proximity Read ↗

Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinomaSemantic proximity Read ↗

SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.Semantic proximity Read ↗

A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human LiverSemantic proximity Read ↗

Extracellular matrix sulfation in the tumor microenvironment stimulates cancer stemness and invasivenessSemantic proximity Read ↗

Hepatic stellate cells promote hepatocellular carcinoma development by regulating histone lactylation: Novel insights from single-cell RNA sequencing and spatial transcriptomics analysesSemantic proximity Read ↗

Tumor Collagens Predict Genetic Features and Patient OutcomesSemantic proximity Read ↗

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.