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A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection

1 Mar 2023

Abstract excerpt

Abstract COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug screens 1,2 . This provided insight into cellular tropism and the host response, yet the molecular mechanisms regulating SARS-CoV-2 infection remain poorly defined. Here we systematically examined...

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PMID: 36918693
DOI: 10.1038/s41556-023-01095-y

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