Article

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

2022-09-21

Abstract excerpt

SARS-CoV-2 primarily infects the respiratory tract, but pulmonary and cardiac complications occur in severe COVID-19. To elucidate molecular mechanisms in the lung and heart, we conducted paired experiments in human stem cell-derived lung alveolar type II (AT2) epithelial cell and cardiac cultures infected with SARS-CoV-2. With CRISPR- Cas9 mediated knock-out of ACE2, we demonstrated that angiotensin converting en...

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Literature Corpus work: 0d122f3a-4e01-59ae-bf5f-9ee93fbe7247
DOI: 10.1101/2022.09.20.508614

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