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Article

Molecular Crosstalk Between MYC and HIF in Cancer

5 Nov 2020

Abstract excerpt

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a central regulator for cells to adapt to low cellular oxygen levels, is also often overexpressed and activated in many human cancers. HIF mediates the primary...

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PMID: 33251216
DOI: 10.3389/fcell.2020.590576

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