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Article

Family-based analysis of the contribution of rare and common genetic variants to school performance in schizophrenia.

Molecular psychiatry - 1 May 2023

Rammos Alexandros, Kirov George, Hubbard Leon, Walters James T R, Holmans Peter, Owen Michael J, O'Donovan Michael C, Rees Elliott

Abstract excerpt

Impaired cognition in schizophrenia is associated with worse functional outcomes. While genetic factors are known to contribute to variation in cognition in schizophrenia, few rare coding variants with strong effects have been identified, and the relative effects from de novo, inherited and non-transmitted alleles are unknown. We used array and exome sequencing data from 656 proband-parent trios to examine the...

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PMID: 36914811
DOI: 10.1038/s41380-023-02013-2
PMCID: PMC10575776

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