Article

Detection of brain somatic variation in epilepsy-associated developmental lesions

2021-12-09

Abstract excerpt

Epilepsy-associated developmental lesions, including malformations of cortical development and low-grade developmental tumors, represent a major cause of drug-resistant seizures requiring surgical intervention in children. Brain-restricted somatic mosaicism has been implicated in the genetic etiology of these lesions; however, many contributory genes remain unidentified. We enrolled 50 children undergoing epilepsy...

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Literature Corpus work: 374d1972-c6d5-5879-b8f9-769794cca900
DOI: 10.1101/2021.12.06.21267079

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