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Article

Phenotypic and functional changes to porcine monocyte-derived macrophages triggered by IL-1β and its receptor antagonist IL-1Ra.

Frontiers in immunology - 1 Jan 2026

Giaconi Emanuela, Mecocci Samanta, Zinellu Susanna, Margarita Valentina, Morrone Sarah, Columbano Nicolò, Bogliolo Luisa, Barroso-Arévalo Sandra, Cappelli Katia, Franzoni Giulia

Abstract excerpt

Pigs are attracting increasing attention as a large-animal model with translational relevance in biomedical research. They share several immunological similarities with humans, although the pig immune system has not been fully characterized yet, also at the level of macrophage polarization. A better understanding of porcine macrophage polarization could improve translational studies, allowing a better...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42609241
DOI: 10.3389/fimmu.2026.1869718
PMCID: PMC13477873

Genes

SLA
CD14
FOS
IL1B
JUN
MAP3K1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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