Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure.

doi:10.1007/s00535-010-0315-4

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Article

Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure.

Journal of gastroenterology - 1 Mar 2011

Xu Zhihui, Ren Xiaoqiang, Liu Yan, Li Xiaodong, Bai Siyu, Zhong Yanwei, Wang Lin, Mao Panyong, Wang Huifen, Xin Shaojie, Wong Vincent Wai-Sun, Chan Henry Lik-Yuen, Zoulim Fabien, Xu Dongping

Abstract excerpt

OBJECTIVE: To investigate the features of hepatitis B virus (HBV) basal core promoter/precore (BCP/PC) mutations and genotypes in a large number of mild/severe chronic hepatitis B (CHB-M/CHB-S), and acute-on-chronic liver failure (ACLF) patients and analyze the clinical implications of the virologic features. PATIENTS AND METHODS: Sera of 793 (325 CHB-M, 170 CHB-S, and 298 ACLF) patients admitted to or who had...

Topics

Adult
Alanine Transaminase
Asian People
Bilirubin
End Stage Liver Disease
Female
Genotype
Hepatitis B e Antigens
Hepatitis B virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B, Chronic

Humans

Liver Failure, Acute

Male

Middle Aged

Mutation

Promoter Regions, Genetic

Sequence Analysis, DNA

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 20848146
DOI: 10.1007/s00535-010-0315-4
PMCID: PMC7088102

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