Identification of the true hyperdiploid multiple myeloma subset by combining conventional karyotyping and FISH analysis

Abstract excerpt

Multiple myeloma (MM) is a malignant disorder of plasma cells representing the second most common hematological malignancy 1 . The currently accepted MM pathogenetic model includes two different types of primary events, namely chromosome translocations or chromosome number alterations resulting in hyperdiploidy 2 . Primary translocations, often associated with hypodiploid karyotype, can be found in at least 40%...