Article
KIT A502_Y503 duplication mutation serves as a potential and universal target for neoantigen peptide in Chinese GIST patients.
Journal of gastroenterology and hepatology - 1 Jul 2023
Liu Fangcen, Wang Qin, Li Yishan, Li Lin, Shi Jiaochun, Fan Xiangshan, Pan Qiuyue, Li Rutian
Abstract excerpt
BACKGROUND AND AIM: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor with high prevalence of KIT and PDGFRA mutations. Few effective treatments can be exploited in imatinib or sunitinib resistant cases. While in immunotherapy, application of the highly individualized cancer neoantigen vaccines is hampered due to high economic and time cost. In this study we identified the most frequent...
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