Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation.

Science China. Life sciences - 1 Dec 2021

Bai Peng, Zhou Qiuping, Wei Pengcheng, Bai Hua, Chan Sanny K, Kappler John W, Marrack Philippa, Yin Lei

Abstract excerpt

Cytotoxic T cells targeting cancer neoantigens harboring driver mutations can lead to durable tumor regression in an HLAI-dependent manner. However, it is difficult to extend the population of patients who are eligible for neoantigen-based immunotherapy, as immunogenic neoantigen-HLA pairs are rarely shared across different patients. Thus, a way to find other human leukocyte antigen (HLA) alleles that can also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Epitopes
Share to HLA-C Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunotherapy

Share to Major Histocompatibility Complex

Share to Neoplasms

Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 33740187
DOI: 10.1007/s11427-020-1888-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation.PMID 33740187Read ↗

Cancer neoantigens as potential targets for immunotherapy.Semantic proximity Read ↗

TSNAdb: A Database for Tumor-Specific Neoantigens from Immunogenomics Data AnalysisSemantic proximity Read ↗

Discovery of prevalent, clinically actionable tumor neoepitopes via integrated biochemical and cell-based platformsSemantic proximity Read ↗

Identification of patient-specific CD4+ and CD8+ T cell neoantigens through HLA-unbiased genetic screens.Semantic proximity Read ↗

Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens.Semantic proximity Read ↗

Advances in personalized neoantigen vaccines for cancer immunotherapy.Semantic proximity Read ↗

Strategies for neoantigen screening and immunogenicity validation in cancer immunotherapy (Review)Semantic proximity Read ↗

ImmuneMirror: a Machine Learning-based Integrative Pipeline and Web Server for Neoantigen PredictionSemantic proximity Read ↗

The Role of Neoantigens in Cancer ImmunotherapySemantic proximity Read ↗

NEPdb: A Database of T-Cell Experimentally-Validated Neoantigens and Pan-Cancer Predicted Neoepitopes for Cancer ImmunotherapySemantic proximity Read ↗

Characterizing neoantigens for personalized cancer immunotherapy.Semantic proximity Read ↗

Computational cancer neoantigen prediction: current status and recent advancesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.