SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19.

doi:10.15252/embr.202256055

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SARS-CoV-2-related bat virus behavior in human-relevant models sheds light on the origin of COVID-19.

EMBO reports - 5 Apr 2023

Temmam Sarah, Montagutelli Xavier, Herate Cécile, Donati Flora, Regnault Béatrice, Attia Mikael, Baquero Salazar Eduard, Chretien Delphine, Conquet Laurine, Jouvion Grégory, Pipoli Da Fonseca Juliana, Cokelaer Thomas, Amara Faustine, Relouzat Francis, Naninck Thibaut, Lemaitre Julien, Derreudre-Bosquet Nathalie, Pascal Quentin, Bonomi Massimiliano, Bigot Thomas, Munier Sandie, Rey Felix A, Le Grand Roger, van der Werf Sylvie, Eloit Marc

Abstract excerpt

Bat sarbecovirus BANAL-236 is highly related to SARS-CoV-2 and infects human cells, albeit lacking the furin cleavage site in its spike protein. BANAL-236 replicates efficiently and pauci-symptomatically in humanized mice and in macaques, where its tropism is enteric, strongly differing from that of SARS-CoV-2. BANAL-236 infection leads to protection against superinfection by a virulent strain. We find no...

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PMID: 36876574
DOI: 10.15252/embr.202256055
PMCID: PMC10074129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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