Article

SARS-CoV-2-Related Bat Virus in Human Relevant Models Sheds Light on the Proximal Origin of COVID-19

2022-06-30

Abstract excerpt

<title>Abstract</title> <p>Bat sarbecovirus BANAL-236 is highly related to SARS-CoV-2 and infects human cells, albeit lacking the furin cleavage site in its spike protein. To inform on the origin of SARS-CoV-2, we evaluated the clinical, epidemiological and evolutionary consequences of a potential BANAL-236 spillover into humans using animal models. The virus replicates efficiently and pauci-symptomatically in hu...

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Literature Corpus work: 760a18d0-af70-5251-934a-6a1c3e8d5fbd
DOI: 10.21203/rs.3.rs-1803095/v1

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