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Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in <i>Rhinolophus</i> and human cells

2025-09-29

Abstract excerpt

Asian Rhinolophus bats are considered the natural reservoirs of an ancestral SARS-CoV-2. However, the biology of SARS-CoV-2-related viruses in bat cells is not well understood. Here, we investigated the replication of BANAL-236, the only bat-derived SARS-CoV-2 relative isolated to date, in Rhinolophus cells. BANAL-236 did not replicate in wild-type Rhinolophus cell lines. Entry assays using pseudoviruses expres...

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Literature Corpus work
537ca278-f558-5202-aca5-14286c1c555d
DOI
10.1101/2025.09.29.679146
Open publication

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Entry, replication and innate immunity evasion of BANAL-236, a SARS-CoV-2-related bat virus, in <i>Rhinolophus</i> and human cellsDOI 10.1101/2025.09.29.679146
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