Article

In COVID-19, <i>NLRP3</i> inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach

2021-09-28

Abstract excerpt

<h4>Background</h4> In COVID-19, the NLRP3 inflammasome is activated in response to SARS-CoV-2 infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is a highly conserved symptom complex that protects against infections and hyperinflammation. <h4>Aims:</h4> To examine the associations of COVID-19, SSC and the NLPR3 rs10157379 T>C and NLPR3 rs10754558 C>G SNV variants; and the protec...

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Literature Corpus work: 83540ff3-9506-5394-a2c2-b632fb0f56a6
DOI: 10.1101/2021.09.26.21264127

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