Article
Spatial Distribution Patterns of Clinically Relevant TERT Promoter Mutations in Follicular Thyroid Tumors of Uncertain Malignant Potential: Advantages of the Digital Droplet PCR Technique.
The Journal of molecular diagnostics : JMD - 1 Feb 2021
Hysek Martin, Jatta Kenbugul, Hellgren L Samuel, Stenman Adam, Larsson Catharina, Zedenius Jan, Juhlin C Christofer
Abstract excerpt
In thyroid carcinomas, telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T predict an unfavorable clinical outcome. The analysis is particularly valuable when assessing histologically equivocal follicular thyroid tumors of uncertain malignant potential (FT-UMPs). Given recent findings of TERT promoter mutational heterogeneity in thyroid cancer, we determined the frequency of this phenomenon...
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