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Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [11C]CURB in Heavy-Drinking Youth.

Biological psychiatry - 1 Sept 2023

Best Laura M, Hendershot Christian S, Buckman Jennifer F, Jagasar Samantha, McPhee Matthew D, Muzumdar Neel, Tyndale Rachel F, Houle Sylvain, Logan Renee, Sanches Marcos, Kish Stephen J, Le Foll Bernard, Boileau Isabelle

Abstract excerpt

BACKGROUND: Reductions in fatty acid amide hydrolase (FAAH), the catabolic enzyme for the endocannabinoid anandamide, may play a role in drinking behavior and risk for alcohol use disorder. We tested the hypotheses that lower brain FAAH levels in heavy-drinking youth are related to increased alcohol intake, hazardous drinking, and differential response to alcohol. METHODS: FAAH levels in the striatum, prefrontal...

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Identifiers

PMID: 36868890
DOI: 10.1016/j.biopsych.2022.11.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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