The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.

doi:10.1038/jcbfm.2015.119

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Article

The fatty acid amide hydrolase C385A variant affects brain binding of the positron emission tomography tracer [11C]CURB.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Aug 2015

Boileau Isabelle, Tyndale Rachel F, Williams Belinda, Mansouri Esmaeil, Westwood Duncan J, Le Foll Bernard, Rusjan Pablo M, Mizrahi Romina, De Luca Vincenzo, Zhou Qian, Wilson Alan A, Houle Sylvain, Kish Stephen J, Tong Junchao

Abstract excerpt

The common functional single-nucleotide polymorphism (rs324420, C385A) of the endocannabinoid inactivating enzyme fatty acid amide hydrolase (FAAH) has been associated with anxiety disorder relevant phenotype and risk for addictions. Here, we tested whether the FAAH polymorphism affects in vivo binding of the FAAH positron emission tomography (PET) probe [(11)C]CURB...

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Identifiers

PMID: 26036940
DOI: 10.1038/jcbfm.2015.119
PMCID: PMC4527995

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FAAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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