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Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan.

Reproductive toxicology (Elmsford, N.Y.) - 1 Jan 2022

Kobayashi Sumitaka, Sata Fumihiro, Ikeda-Araki Atsuko, Miyashita Chihiro, Goudarzi Houman, Iwasaki Yusuke, Nakajima Tamie, Kishi Reiko

Abstract excerpt

We assessed the associations between perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) levels in third trimester maternal serum, the maternal genotypes of genes encoding nuclear receptors, and birth outcomes. We studied a prospective birth cohort of healthy pregnant Japanese women (n = 372) recruited in Sapporo between July 2002 and October 2005. We analyzed PFOS and PFOA levels using liquid...

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PMID: 34896592
DOI: 10.1016/j.reprotox.2021.12.004

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